Histomorphometeric Study of Lymphoid Nodules of Vermiform

Histomorphometeric Study of Lymphoid Nodules of Vermiform ABSTRACT Objective: To study the lymphoid tissues of vermiform Appendix at various age groups to establish that appendix is an important organ of gut associated lymphoid tissue (GALT) and its role in etiology of acute appendicitis. Study Design: Comparative study Place and duration: The study was conducted at Islamic International Medical College Rawalpindi from July 2011 to June 2013. Materials and Methods: Four age groups spacing 15 years between each group, except last group (advanced age) which had no limit because of less availability of the specimens, were made. In each group histological sections of 10 normal looking surgically amputated vermiform appendices were included. The parameters including number of lymphoid nodules and diameter of lymphoid nodules measured under the microscope. Results: There was gradual decrease of mean number of lymphoid nodules with advancing age but even at the age of 74 few numbers of lymphoid nodules were observed. There was great variation of diameter of lymphoid nodule at different age groups but at advanced age it was much decreased. Conclusion: The lymphoid nodules decreased with advancing age but these were present even at the age of 74 years. The diameters of lymphoid nodules are remarkable except at advanced age. Key words: Vermiform appendix, lymphoid nodule, Microscope. Introduction The clinical presentations associated with this blind ending tube (vermiform appendix) are so many and diverse that many lives have been lost in the past either due to misdiagnosis, mismanagement or complications associated with it. The appendix length varies from 2 to 20 cm with an average of 9 cm.1 The variable number of lymphoid nodules located in the lamina propria extending to sub-mucosa, are arranged circumferentially around the lumen of the appendix. The crypts of Lieberkuhn are absent between epithelial lining and lymphoid nodules at places where the lymphoid nodules are close to epithelial lining. Zahid A. observed that the vermiform appendix is an important component of mammalian mucosal immune function, particularly B-lymphocyte-mediated immune responses and T-lymphocytes derived extra-thymically and it is also suggested that vermiform appendix is not a vestigial organ.2 The normal function of appendix probably helps to promote local immunity.3 The appendix contains both isolated and aggregated lymphoid follicles and it is a part of gut associated lymphoid tissue (GALT).4 The irregularity of the lumen of vermiform appendix is due to mucosal folds which appear due to lymphoid follicles.5 The lymphoid nodules appear in the vermiform appendix about two weeks after birth6. In full term human fetus there is no obvious lymphoid tissue seen in the vermiform appendix but two well organized lymphoid nodules are observed within first two weeks and about 10-12 well organized and prominent lymphoid nodules are visible in transverse section of vermiform appendix of man of thirty two weeks old.7 As the age advances, the weight of the appendix decreases because number and size of lymphoid nodules reduces. In or near appendix, in any pathology, the primary and secondary immune response is high in young age. Materials and Methods This study was conducted at Islamic International Medical College Rawalpindi from July 2011 to June 2013. In this study, a total of 40 normally looking surgically amputated vermiform appendix specimens were included. According to age, these specimens were divided into four equal groups. Each group consists of 10 specimens with spacing of 15 years between each group except the last group. Due to less availability of appendices, the last group ranges from 46-74 years. The groups were as follow: Group A: 0- 15 years Group B: 16-30 years Group C: 31-45 years Group D: 46-74 years The 5 micrometer thickness sectioning of tissue blocks with microtome made. The specimens stained with Haemotoxylin and Eosin. Only the results of middle part of the vermiform appendix are included in this study. The histological slides were examined under the light microscope after calibration of ocular micrometer. Procedure for measurement of the diameter of the lymphoid follicle The measurements were taken twice for each nodules, one was taken among the maximum transverse diameter and another at perpendicular to the first one. Then the number of micrometer divisions were multiplied by the correlation factor derived earlier keeping the magnification constant. Diameter of the lymphoid follicle was calculated as: Maximum transverse Diameter + Perpendicular diameter Diameter of lymphoid follicle = 2 By using the above formula the diameter of all lymphoid nodules of each slide were measured and then mean diameter of each slide calculated. Then the mean diameter of each group calculated as shown in the tables. Discussion At different age groups, the microanatomy of appendix is variable. The lumen size and wall thickness depends on number and diameter of lymphoid nodules. There are large numbers of lymphoid nodules in the vermiform appendix and it is a part of Gut Associated Lymphoid Tissue (GALT). It is proposed by Zahid A. that appendix perform to train immune system of the body for production of antibodies when exposed to antigen and also play a role in foetal development by manufacturing hormones.2 In this study, the highest number of lymphoid nodules (10.3) is in the group B (16- 30 years) and the lowest number of lymphoid nodules (3.8) is in the group D (46-74 years). In a Bangladesh study8, the highest number of lymphoid follicles was in age group up to 20 years and lowest in age group between 56-70 years and similarly the diameter of lymphoid follicles is highest in age group up to 20 years and lowest in age group of 56-70 years but the age grouping was somewhat different from our study. In another study, the highest average diameter of lymphoid follicles was found in group 0-20 years and lowest average diameter was found above 50 years age.9 The above referred study agreed with Borley5 and Arey.10 In another Bangladesh study11 the mean numbers of lymphoid nodules are less than half of our study. In old age, the numbers of the lymphoid nodules are reduced and these are replaced by fibrous tissue.11,12 It is observed in our study, that although the mean number of lymphoid nodules is lowest (3.8) in group D (45-74Years) but even at the ages of 60 years, 63 years, and 65 years, the number of lymphoid nodules are equivalent to some specimens of group A, B, and C. Even at the age of 74 years three lymphoid nodules were found. Although the lymphoid nodules and other structures in the wall of appendix are replaced by fibrous tissue in old age but normally it is also observed in many adults13. The germinal centers in most of the lymphoid nodules of human appendix are present in the children up to16 years of age but the number of germinal centers are less in adults and they are absent in the nodules in old age persons.14 In our study the germinal centers were not explored. Like the vermiform appendix, the Peyer’s patches (Lymphoid nodules) which are concentrated at distal 25cm of ileum are more numerous in young adults and they become less prominent as age advances.15, 16 Conclusion The lymphoid nodules decreased with advancing age but these were present even at the age of 74 years. The diameters of lymphoid nodules are remarkable except at advanced age. Ann. Pak. Inst. Med. Sci. 2014; 10(3): 161-1641

Week 1 Assignment

Working for a big company, there is always something new to learn and new work that comes our way. There are many different personalities. We were always training and learning new material and tools to use to make our work more effective and productive. We would have meetings that were hours long so everyone can train on the new work and tools we had coming our way. Most of the people were struggling to learn the new tools. I was taking a class in which we were learning about peoples’ different learning styles. I thought all the training we were doing would be a great project for the class I was taking.I brought it to my bosses’ attention that I think that people are not learning because everyone has a different learning style. She was convinced that people were just tired and busy that’s why they could not understand the material. I wanted to test this theory. I suggested if we can give the employees on our team a learning test to see which way they better leane d. The results were exactly what I thought they were. Everyone had different learning styles. It turns out that most of the people on our team learned best Hands-On. Others were visual and the rest learned best by reading the material.This type of research method is best described as Correlation Research (positive correlation) because I was determining if two sets of variables are associated and if the variables increase or decrease. In this case when people used a learning method that fit best for them, they had better results for learning. When they were using a learning method that was not best for them, they were not learning the material. If I could have done anything different it would have been to test peoples’ personalities to determine if certain personalities learned a certain way. This would have gone more in depth as to why people learn the way they do.

Online Clinic Management System

I. Company Profile Established in November, 2008, the Villa-Santarromana Dental Clinic provides quality dental services to private clients who prefer dental treatments in a friendly and caring environment. The clinic was managed and owned by Dr. Karen Francia S. Villa. It is located in the city proper of Luna, La Union. They offer services in the field of General Dentistry, Orthodontics, and Cosmetic Dentistry. As for the moment it has a huge amount of clients who comes every day for dental services.We all know that modern clinics are now operating at great pace striving to serve as many patients as possible with the best of their abilities. But as the years rolled by, prescriptions, billing and appointment schedule, is no longer practical. In this study, we hope to develop a web-based application that will minimize all paper works and manual records keeping, therefore allowing doctors and staff ease in keeping track of patients.Reducing patients’ waiting time and increasing t he number of patients served a system that is fully automated, user-friendly, time effective and efficient. II. Problem Definition A. General Problem: The main problem of Villa-Santarromana Dental Clinic is that they have the manual way on recording, tracking, and managing patients request which sometimes lead to slower transaction within the clients. B. Specific Problem: New and regular patient’s records was recorded manually; * Billing statement and its official receipt is done manually; * Tracking regular patients; * Scheduling of services; * Tallying of monthly income. III. Objectives A. General Objective This study was aimed to designed and develop an online clinic management solution that will serve as proposal to help the dentist and staff to save time and resources with the automation of its daily clinic operations.Specifically this study was aimed to: * To computerize record keeping of patients; * To allow dentist retrieve complete patient instantly; * To automate bi lling statement and official receipt; * To automate medical prescription and medical certificates. IV. Project Description Project Goal: The focus of this study is to create an online clinic management system that will greatly improve the efficiency and quality of care in clinical practice. The system covers the profile of the client’s personal information; * The system tracks the records of the regular clients; * The system will have an automated billing statement and official reciepts; * The system will record, update, store, organize, and retrieve patient’s records. * Web-access of the patients is not included; * The system has a secure log-in for dentist and staff; * Managing appointment is also integrated; * Automated medical prescriptions and medical certificates.

Are The Police Our Friends - 1211 Words

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